See other answers re: the non-advisability of this. That said you can make a pretty robust sandbox:
derive a CSS selector that finds the main content area, both with and without the sidebar:
table#bodyTable > tbody > tr > td:last-child
take a CSS reset and boost its specificity so it dominates that main content area (a table cell):
prefix all your selectors with the same CSS selector so they don't trample the Salesforce styles
Here's one I prepared earlier:
table#bodyTable > tbody > tr > td:last-child html,
table#bodyTable > tbody > tr > td:last-child body,
table#bodyTable > tbody > tr > td:last-child div,
table#bodyTable > tbody > tr > td:last-child span,
table#bodyTable > tbody > tr > td:last-child applet,
table#bodyTable > tbody > tr > td:last-child object,
table#bodyTable > tbody > tr > td:last-child iframe,
table#bodyTable > tbody > tr > td:last-child h1,
table#bodyTable > tbody > tr > td:last-child h2,
table#bodyTable > tbody > tr > td:last-child h3,
table#bodyTable > tbody > tr > td:last-child h4,
table#bodyTable > tbody > tr > td:last-child h5,
table#bodyTable > tbody > tr > td:last-child h6,
table#bodyTable > tbody > tr > td:last-child p,
table#bodyTable > tbody > tr > td:last-child blockquote,
table#bodyTable > tbody > tr > td:last-child pre,
table#bodyTable > tbody > tr > td:last-child a,
table#bodyTable > tbody > tr > td:last-child abbr,
table#bodyTable > tbody > tr > td:last-child acronym,
table#bodyTable > tbody > tr > td:last-child address,
table#bodyTable > tbody > tr > td:last-child big,
table#bodyTable > tbody > tr > td:last-child cite,
table#bodyTable > tbody > tr > td:last-child code,
table#bodyTable > tbody > tr > td:last-child del,
table#bodyTable > tbody > tr > td:last-child dfn,
table#bodyTable > tbody > tr > td:last-child em,
table#bodyTable > tbody > tr > td:last-child img,
table#bodyTable > tbody > tr > td:last-child ins,
table#bodyTable > tbody > tr > td:last-child kbd,
table#bodyTable > tbody > tr > td:last-child q,
table#bodyTable > tbody > tr > td:last-child s,
table#bodyTable > tbody > tr > td:last-child samp,
table#bodyTable > tbody > tr > td:last-child small,
table#bodyTable > tbody > tr > td:last-child strike,
table#bodyTable > tbody > tr > td:last-child strong,
table#bodyTable > tbody > tr > td:last-child sub,
table#bodyTable > tbody > tr > td:last-child sup,
table#bodyTable > tbody > tr > td:last-child tt,
table#bodyTable > tbody > tr > td:last-child var,
table#bodyTable > tbody > tr > td:last-child b,
table#bodyTable > tbody > tr > td:last-child u,
table#bodyTable > tbody > tr > td:last-child i,
table#bodyTable > tbody > tr > td:last-child center,
table#bodyTable > tbody > tr > td:last-child dl,
table#bodyTable > tbody > tr > td:last-child dt,
table#bodyTable > tbody > tr > td:last-child dd,
table#bodyTable > tbody > tr > td:last-child ol,
table#bodyTable > tbody > tr > td:last-child ul,
table#bodyTable > tbody > tr > td:last-child li,
table#bodyTable > tbody > tr > td:last-child fieldset,
table#bodyTable > tbody > tr > td:last-child form,
table#bodyTable > tbody > tr > td:last-child label,
table#bodyTable > tbody > tr > td:last-child legend,
table#bodyTable > tbody > tr > td:last-child table,
table#bodyTable > tbody > tr > td:last-child caption,
table#bodyTable > tbody > tr > td:last-child tbody,
table#bodyTable > tbody > tr > td:last-child tfoot,
table#bodyTable > tbody > tr > td:last-child thead,
table#bodyTable > tbody > tr > td:last-child tr,
table#bodyTable > tbody > tr > td:last-child th,
table#bodyTable > tbody > tr > td:last-child td,
table#bodyTable > tbody > tr > td:last-child article,
table#bodyTable > tbody > tr > td:last-child aside,
table#bodyTable > tbody > tr > td:last-child canvas,
table#bodyTable > tbody > tr > td:last-child details,
table#bodyTable > tbody > tr > td:last-child embed,
table#bodyTable > tbody > tr > td:last-child figure,
table#bodyTable > tbody > tr > td:last-child figcaption,
table#bodyTable > tbody > tr > td:last-child footer,
table#bodyTable > tbody > tr > td:last-child header,
table#bodyTable > tbody > tr > td:last-child hgroup,
table#bodyTable > tbody > tr > td:last-child menu,
table#bodyTable > tbody > tr > td:last-child nav,
table#bodyTable > tbody > tr > td:last-child output,
table#bodyTable > tbody > tr > td:last-child ruby,
table#bodyTable > tbody > tr > td:last-child section,
table#bodyTable > tbody > tr > td:last-child summary,
table#bodyTable > tbody > tr > td:last-child time,
table#bodyTable > tbody > tr > td:last-child mark,
table#bodyTable > tbody > tr > td:last-child audio,
table#bodyTable > tbody > tr > td:last-child video {
margin: 0;
padding: 0;
border: 0;
font-size: 100%;
font: inherit;
vertical-align: baseline;
}
/* HTML5 display-role reset for older browsers */
table#bodyTable > tbody > tr > td:last-child article,
table#bodyTable > tbody > tr > td:last-child aside,
table#bodyTable > tbody > tr > td:last-child details,
table#bodyTable > tbody > tr > td:last-child figcaption,
table#bodyTable > tbody > tr > td:last-child figure,
table#bodyTable > tbody > tr > td:last-child footer,
table#bodyTable > tbody > tr > td:last-child header,
table#bodyTable > tbody > tr > td:last-child hgroup,
table#bodyTable > tbody > tr > td:last-child menu,
table#bodyTable > tbody > tr > td:last-child nav,
table#bodyTable > tbody > tr > td:last-child section {
display: block;
}
table#bodyTable > tbody > tr > td:last-child {
line-height: 1;
}
table#bodyTable > tbody > tr > td:last-child ol,
table#bodyTable > tbody > tr > td:last-child ul {
list-style: none;
}
table#bodyTable > tbody > tr > td:last-child blockquote,
table#bodyTable > tbody > tr > td:last-child q {
quotes: none;
}
table#bodyTable > tbody > tr > td:last-child blockquote:before,
table#bodyTable > tbody > tr > td:last-child blockquote:after,
table#bodyTable > tbody > tr > td:last-child q:before,
table#bodyTable > tbody > tr > td:last-child q:after {
content: '';
content: none;
}
table#bodyTable > tbody > tr > td:last-child table {
border-collapse: collapse;
border-spacing: 0;
}