No. Edit Read Only Fields is the override for both configurable Read-Only flags, namely Field Level Security and Page Layout configuration. Your choices are either a validation rule or some logic (Before Save Flow, Trigger, Workflow Field Update, Processes) to revert the value during/after saving.
It is not possible to assign two different page layouts to the same profile.
But with Salesforce Lightning, at least there is a way to achieve this by using Related Record component and the Component Visibility setting in the Lightning Record Page.
What you need to do:
Create two Quick Actions (Update Record) in your Lead object. Eg. Update Country Canada ...