Simply turn:
AND (Response_Begin_Code__c = 'E' AND Response_Status_Code__c = 'NA')
into:
AND Response_Begin_Code__c != 'E' AND Response_Status_Code__c != 'NA'
Simply turn:
AND (Response_Begin_Code__c = 'E' AND Response_Status_Code__c = 'NA')
into:
AND Response_Begin_Code__c != 'E' AND Response_Status_Code__c != 'NA'