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Validation rule for your conditions:

1. RecordType = "Clinical Studies"
2. Status__c = "Draft"
3. Start_Date__c && End_Date__c are changed.
4. Date_Change_Reason__c should not be null.

AND( 
  $RecordType.Name = "Clinical Studies",
  ISPICKVAL(Status__c,"Draft"),
  ISCHANGED(Start_Date__c),
  ISCHANGED(End_Date__c),
  NOT(
    ISBLANK(Date_Change_Reason__c)
  )
)