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Validation rule for your conditions:

1. RecordType = "Clinical Studies"

2. Status__c = "Draft"

3. Start_Date__c && End_Date__c are changed.

4. Date_Change_Reason__c should not be null.

   AND( $RecordType.Name = "Clinical Studies", ISPICKVAL(Status__c,"Draft"), ISCHANGED(Start_Date__c), ISCHANGED(End_Date__c), NOT( ISBLANK(Date_Change_Reason__c)))