This Validation Rule formula on Contact works and fires when a Case Manager tries to edit the record. So far so good; they should not have access when the picklist value is as shown. But two Users with that same Profile do need access, and they have the Role of Lead Case Manager. I've tried this formula, but the VR is still firing for them and they cannot edit.
$Profile.Name = "Case Manager"
&&
$UserRole.Name <> 'Lead_Case_Manager'
&&
CONTAINS(TEXT(Case_Status__c), "Submitted for Review")