I think you have Link Tracking in mind. If you track clicks on the links in your email, they all will be redirected to capture the click info, which means that they will go through
http://cl.exct.net/. The original URL will be replaced with a new one that routes to Marketing Cloud click processors.
In order to disable tracking and have the links go straight to the URL you provided, use the Concat AMPscript function, like in this example from the documentation:
Set @URL = "<a href='http://google.com'>Google 1</a>"
Bare in mind, that this will preserve the original URL, but you won't be able to track clicks on this URL inside Marketing Cloud. You can still track them in Google Analytics or a similar tool, if you add utm parameters to the link.
Read more here: Stop a link from being tracked in a Marketing Cloud email