Is it possible to develop an iOS app (with Swift/Obj C/XCode as front end tools) and Salesforce (Database.com) as backend ?
The communication between the app and Database.com to be done only on REST calls.
Has anyone used such a setup ?
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Yes it is possible. You can use salesforce backend for Android as well. You need to use Mobile SDK of Salesoforce to build to those applications. Please check this link. As @Eric pointed out if you are using REST API's then you've got some governor limits which needs to taken care of. Here is one more link for developing native iOS app. Getting Started in Mobile Development with iOS using Salesforce Hope I answered your question