Using a sendable data extension containing an Id column connected to Subscriber Key, we are sending two emails to the recipients inside the data extension. If we encounter opt-outs and bounces during the first send, does SFMC remove them automatically or should they be handled manually using e.g. using excluded lists in the User-initiated Send?
I'm wondering if there's an official documentation about this.
There is a good description of how bounce management is handled by SFMC in this help article. Especially the decision tree provides an easy overview when a recipient is excluded from email sends:
When it comes to opt-outs, it depends on how you handle them. If someone opts out "programatically" (i.e. by list-unsubscribe header), this is registered on All Subscribers and this person will no longer receive your emails. If you are using a custom preference center, this behaviour will still be valid, however your regular opt-out link will probably update a consent record in a data extension, and your segmentation should exclude this person from future sends.
